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Article

Autophagy is involved in TGF-β1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment.

Oncotarget - 26 Jan 2016

Liu Fang-Lan, Mo En-Pan, Yang Liu, Du Jun, Wang Hong-Sheng, Zhang Huan, Kurihara Hiroshi, Xu Jun, Cai Shao-Hui

Abstract excerpt

Transforming growth factor-β1 (TGF-β1) present in tumor microenvironment acts in a coordinated fashion to either suppress or promote tumor development. However, the molecular mechanisms underlying the effects of TGF-β1 on tumor microenvironment are not well understood. Our clinical data showed a positive association between TGF-β1 expression and cancer-associated fibroblasts (CAFs) in tumor microenvironment of...

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Identifiers

PMID: 26716641
DOI: 10.18632/oncotarget.6702
PMCID: PMC4826194

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