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Article

Development of Fok-I based nested polymerase chain reaction-restriction fragment length polymorphism analysis for detection of hepatitis B virus X region V5M mutation.

World journal of gastroenterology - 21 Dec 2015

Kim Hong, Hong Seok-Hyun, Lee Seoung-Ae, Gong Jeong-Ryeol, Kim Bum-Joon

Abstract excerpt

AIM: To develop a Fok-I nested polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis (PRA) method for the detection of hepatitis B virus X region (HBx) V5M mutation. METHODS: Nested PCR was applied into DNAs from 198 chronic patients at 2 different stages [121 patients with hepatocellular carcinoma (HCC) and 77 carrier patients]. To identify V5M mutants, digestion of nested PCR...

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Identifiers

PMID: 26715821
DOI: 10.3748/wjg.v21.i47.13360
PMCID: PMC4679770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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