Article
Polymorphisms in the IL-6 and IL-6R receptor genes as new diagnostic biomarkers of acute appendicitis: a study on two candidate genes in pediatric patients with acute appendicitis.
Italian journal of pediatrics - 29 Dec 2015
Sarsu Sevgi Büyükbeşe, Yılmaz Şenay Görücü, Bayram Ali, Denk Affan, Kargun Kürşat, Sungur Mehmet Ali
Abstract excerpt
BACKGROUND: Acute appendicitis (AA) (OMIM: 107700) is an inflammatory disease which is characterized by appendiceal inflammation. Genetic and environmental factors contribute to the development of AA. Especially, multiple genetic factors appear to be promising in the explanation of etiopathogenesis of AA. IL-6 (Interleukin-6) is an inflammatory cytokine and IL-6 receptor (IL-6R) plays an important role in the...
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