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Structural and functional analysis of RopB: a major virulence regulator in S treptococcus pyogenes

29 Dec 2015

Abstract excerpt

Group A Streptococcus (GAS) is an exclusive human pathogen that causes significant disease burden. Global regulator RopB of GAS controls the expression of several major virulence factors including secreted protease SpeB during high cell density. However, the molecular mechanism for RopB-dependent speB expression remains unclear. To understand the mechanism of transcription activation by RopB, we determined the...

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PMID: 26714274
DOI: 10.1111/mmi.13294

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