Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder.

doi:10.1073/pnas.1513525113

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Article

Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2016

Pagani Lucia, St Clair Patricia A, Teshiba Terri M, Service Susan K, Fears Scott C, Araya Carmen, Araya Xinia, Bejarano Julio, Ramirez Margarita, Castrillón Gabriel, Gomez-Makhinson Juliana, Lopez Maria C, Montoya Gabriel, Montoya Claudia P, Aldana Ileana, Navarro Linda, Freimer Daniel G, Safaie Brian, Keung Lap-Woon, Greenspan Kiefer, Chou Katty, Escobar Javier I, Ospina-Duque Jorge, Kremeyer Barbara, Ruiz-Linares Andres, Cantor Rita M, Lopez-Jaramillo Carlos, Macaya Gabriel, Molina Julio, Reus Victor I, Sabatti Chiara, Bearden Carrie E, Takahashi Joseph S, Freimer Nelson B

Abstract excerpt

Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained from members of 26 Costa Rican and Colombian pedigrees [136 euthymic (i.e., interepisode) BP-I individuals and 422...

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PMID: 26712028
DOI: 10.1073/pnas.1513525113
PMCID: PMC4760829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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