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Article

The demographic history and mutational load of African hunter-gatherers and farmers.

Nature ecology & evolution - 1 Apr 2018

Lopez Marie, Kousathanas Athanasios, Quach Hélène, Harmant Christine, Mouguiama-Daouda Patrick, Hombert Jean-Marie, Froment Alain, Perry George H, Barreiro Luis B, Verdu Paul, Patin Etienne, Quintana-Murci Lluís

Abstract excerpt

Understanding how deleterious genetic variation is distributed across human populations is of key importance in evolutionary biology and medical genetics. However, the impact of population size changes and gene flow on the corresponding mutational load remains a controversial topic. Here, we report high-coverage exomes from 300 rainforest hunter-gatherers and farmers of central Africa, whose distinct subsistence...

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PMID: 29531345
DOI: 10.1038/s41559-018-0496-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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