Article
Mutation in the Hepatitis E Virus Polymerase and Outcome of Ribavirin Therapy.
Antimicrobial agents and chemotherapy - 28 Dec 2015
Lhomme Sebastien, Kamar Nassim, Nicot Florence, Ducos Jacques, Bismuth Michael, Garrigue Valerie, Petitjean-Lecherbonnier Joelle, Ollivier Isabelle, Alessandri-Gradt Elodie, Goria Odile, Barth Heidi, Perrin Peggy, Saune Karine, Dubois Martine, Carcenac Romain, Lefebvre Caroline, Jeanne Nicolas, Abravanel Florence, Izopet Jacques
Abstract excerpt
Hepatitis E virus (HEV) can lead to chronic infection in solid-organ transplant patients. Ribavirin is efficient for treatment of chronically infected patients. Recently, the1634R mutation in the HEV polymerase has been associated with treatment failure. However, it is unclear if this mutation can be used as a prognostic marker of treatment outcome. We studied the prevalence of the 1634R mutation in the HEV...
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