Proteome Differences between Hepatitis B Virus Genotype-B- and Genotype-C-Induced Hepatocellular Carcinoma Revealed by iTRAQ-Based Quantitative Proteomics.

doi:10.1021/acs.jproteome.5b00838

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Article

Proteome Differences between Hepatitis B Virus Genotype-B- and Genotype-C-Induced Hepatocellular Carcinoma Revealed by iTRAQ-Based Quantitative Proteomics.

Journal of proteome research - 5 Feb 2016

Wei Dahai, Zeng Yongyi, Xing Xiaohua, Liu Hongzhi, Lin Minjie, Han Xiao, Liu Xiaolong, Liu Jingfeng

Abstract excerpt

Hepatitis B virus (HBV) is the main cause of hepatocellular carcinoma (HCC) in southeast Asia where HBV genotype B and genotype C are the most prevalent. Viral genotypes have been reported to significantly affect the clinical outcomes of HCC. However, the underlying molecular differences among different genotypes of HBV virus infected HCC have not been revealed. Here, we applied isobaric tags for relative and...

Topics

Biomarkers, Tumor
Carcinoma, Hepatocellular
Chromatography, Liquid
Female
Gene Expression Regulation, Neoplastic
Gene Ontology
Genotype
Hepatitis B
Hepatitis B virus
Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Isotope Labeling

Liver Neoplasms

Male

Middle Aged

Proteome

Proteomics

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 26709725
DOI: 10.1021/acs.jproteome.5b00838

Genes

ANXA1
ARFIP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26709725-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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