Article
High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222.
International journal of oncology - 1 Mar 2016
Brognara Eleonora, Fabbri Enrica, Montagner Giulia, Gasparello Jessica, Manicardi Alex, Corradini Roberto, Bianchi Nicoletta, Finotti Alessia, Breveglieri Giulia, Borgatti Monica, Lampronti Ilaria, Milani Roberta, Dechecchi Maria Cristina, Cabrini Giulio, Gambari Roberto
Abstract excerpt
The biological activity of a combined treatment of U251, U373 and T98G glioma cell lines with two anti-miR PNAs, directed against miR‑221 and miR‑222 and conjugated with an ocataarginine tail (R8-PNA-a221 and R8-PNA-a222) for efficient cellular delivery, was determined. Apoptosis was analyzed, and the effect of the combined treatment of glioma cells with either or both PNAs on the reversion of drug-resistance...
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