Article
miR-221/222 promote malignant progression of glioma through activation of the Akt pathway.
International journal of oncology - 1 Apr 2010
Zhang Junxia, Han Lei, Ge Youlin, Zhou Xuan, Zhang Anling, Zhang Chunzhi, Zhong Yue, You Yongping, Pu Peiyu, Kang Chunsheng
Abstract excerpt
MicroRNAs (miRNAs) are short regulatory RNAs that negatively modulate protein expression at a post-transcriptional level. Emerging evidence suggests that miRNAs play important roles in the pathogenesis of several types of cancers. However, the further mechanisms of miRNA remain unknown. In this study, we aimed to explore the coordinated function of miR-221/222 in glioma by bioinformatics and experiment methods....
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