Article
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia.
Communications biology - 7 Sept 2020
Guan Yihong, Greenberg Edward F, Hasipek Metis, Chen Shi, Liu Xiaochen, Kerr Cassandra M, Gackowski Daniel, Zarakowska Ewelina, Radivoyevitch Tomas, Gu Xiaorong, Willard Belinda, Visconte Valeria, Makishima Hideki, Nazha Aziz, Mukherji Mridul, Sekeres Mikkael A, Saunthararajah Yogen, Oliński Ryszard, Xu Mingjiang, Maciejewski Jaroslaw P, Jha Babal K
Abstract excerpt
Loss-of-function TET2 mutations (TET2MT) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize 5-methylcytosine. TET2MT thus result in hypermethylation and transcriptional repression. Ascorbic acid (AA) increases dioxygenase activity by facilitating Fe(III)/Fe(II) redox reaction and may alleviate some biological consequences of TET2MT by restoring dioxygenase...
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