Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation.

The Journal of biological chemistry - 26 Feb 2016

Law Nathan C, Hunzicker-Dunn Mary E

Abstract excerpt

The ubiquitous phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates many cellular functions. However, the mechanism by which G protein-coupled receptors (GPCRs) signal to activate PI3K is poorly understood. We have used ovarian granulosa cells as a model to investigate this pathway, based on evidence that the GPCR agonist follicle-stimulating hormone (FSH) promotes the protein kinase A (PKA)-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP-Dependent Protein Kinases
Share to Follicle Stimulating Hormone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Granulosa Cells

Share to Insulin-Like Growth Factor I

Share to Insulin Receptor Substrate Proteins

Share to Phosphatidylinositol 3-Kinase

Share to Protein Phosphatase 1

Share to Receptor, IGF Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 26702053
DOI: 10.1074/jbc.M115.698761
PMCID: PMC4813480

Genes

IRS1
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation.PMID 26702053Read ↗

The insulin-like growth factor and its players: their functions, significance, and consequences in all aspects of ovarian physiologySemantic proximity Read ↗

Genome-wide interactions between FSH and insulin-like growth factors in the regulation of human granulosa cell differentiationSemantic proximity Read ↗

GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation SitesSemantic proximity Read ↗

TRIB3 Regulates FSHR Expression in Human Granulosa Cells Under High Levels of Free Fatty AcidsSemantic proximity Read ↗

Phosphatidyl-inositol-3 kinase-independent insulin action pathway(s) in the human ovary.Semantic proximity Read ↗

Conserved insulin signaling in the regulation of oocyte growth, development, and maturationSemantic proximity Read ↗

FSH Regulates IGF-2 Expression in Human Granulosa Cells in an AKT-Dependent MannerSemantic proximity Read ↗

Recent discoveries in physiology of insulin-like growth factor-1 and its interaction with gonadotropins in folliculogenesis.Semantic proximity Read ↗

Follicle stimulating hormone receptor expression in human pancreas and effects on insulin secretion: A translational studySemantic proximity Read ↗

Protein Kinase A: A Master Kinase of Granulosa Cell Differentiation.Semantic proximity Read ↗

Human Follicle-Stimulating Hormone (FSH) Receptor Interacts with the Adaptor Protein APPL1 in HEK 293 Cells: Potential Involvement of the PI3K Pathway in FSH Signaling1Semantic proximity Read ↗

PI3K: An Attractive Candidate for the Central Integration of Metabolism and ReproductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.