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Article

FSH Regulates IGF-2 Expression in Human Granulosa Cells in an AKT-Dependent Manner

12 Jun 2015

Abstract excerpt

CONTEXT: IGF-2 is highly expressed in the granulosa cells of human dominant ovarian follicles; however, little is known about the regulation of the IGF-2 gene or the interaction of IGF-2 and FSH during follicle development. OBJECTIVE: To examine the mechanisms involved in the regulation of the IGF-2 gene by FSH and the interplay between FSH and IGF-2 during granulosa cell differentiation. Design, Setting,...

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Share to Growth Hormone and Insulin-like Growth Factors
Share to Ovarian function and disorders
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PMID: 26066673
DOI: 10.1210/jc.2015-1504

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