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Genome-wide interactions between FSH and insulin-like growth factors in the regulation of human granulosa cell differentiation

5 Jan 2017

Abstract excerpt

Study question: Is the genome-wide response of human cumulus cells to FSH and insulin-like growth factors (IGFs) comparable to the response observed in undifferentiated granulosa cells (GCs)? Summary answer: FSH actions in human cumulus cells mimic those observed in preantral undifferentiated GCs from laboratory animals, and approximately half of the regulated genes are dependent on the simultaneous activation of...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 28158425
DOI: 10.1093/humrep/dex002

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