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Article

Phage-associated mutator phenotype in group A streptococcus.

Journal of bacteriology - 1 Oct 2008

Scott Julie, Thompson-Mayberry Prestina, Lahmamsi Stephanie, King Catherine J, McShan W Michael

Abstract excerpt

Defects in DNA mismatch repair (MMR) occur frequently in natural populations of pathogenic and commensal bacteria, resulting in a mutator phenotype. We identified a unique genetic element in Streptococcus pyogenes strain SF370 that controls MMR via a dynamic process of prophage excision and reintegration in response to growth. In S. pyogenes, mutS and mutL are organized on a polycistronic mRNA under control of a...

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Identifiers

PMID: 18676670
DOI: 10.1128/JB.01569-07
PMCID: PMC2565987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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