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Article

TrpE feedback mutants reveal roadblocks and conduits toward increasing secondary metabolism in Aspergillus fumigatus.

Fungal genetics and biology : FG & B - 1 Apr 2016

Wang Pin-Mei, Choera Tsokyi, Wiemann Philipp, Pisithkul Tippapha, Amador-Noguez Daniel, Keller Nancy P

Abstract excerpt

Small peptides formed from non-ribosomal peptide synthetases (NRPS) are bioactive molecules produced by many fungi including the genus Aspergillus. A subset of NRPS utilizes tryptophan and its precursor, the non-proteinogenic amino acid anthranilate, in synthesis of various metabolites such as Aspergillus fumigatus fumiquinazolines (Fqs) produced by the fmq gene cluster. The A. fumigatus genome contains two...

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Identifiers

PMID: 26701311
DOI: 10.1016/j.fgb.2015.12.002
PMCID: PMC4789178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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