Article
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2016
Ferré Cécile A, Davezac Noélie, Thouard Anne, Peyrin Jean-Michel, Belenguer Pascale, Miquel Marie-Christine, Gonzalez-Dunia Daniel, Szelechowski Marion
Abstract excerpt
To favor their replication, viruses express proteins that target diverse mammalian cellular pathways. Due to the limited size of many viral genomes, such proteins are endowed with multiple functions, which require targeting to different subcellular compartments. One salient example is the X protein of Borna disease virus, which is expressed both at the mitochondria and in the nucleus. Moreover, we recently...
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