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Article

Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor-associated kinase 4.

The Journal of pediatrics - 1 Nov 2004

Enders Anselm, Pannicke Ulrich, Berner Reinhard, Henneke Phillip, Radlinger Klaus, Schwarz Klaus, Ehl Stephan

Abstract excerpt

We describe two siblings with one confirmed and one inferred homozygous base pair deletion in the gene for interleukin-1-related kinase 4 (IRAK-4) who died of pneumococcal meningitis at 2 and 14 months, respectively. Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections.

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Fatal Outcome
Immune Tolerance
Infant
Interleukin-1 Receptor-Associated Kinases
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphotransferases (Alcohol Group Acceptor)

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PMID: 15520784
DOI: 10.1016/j.jpeds.2004.06.065

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