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Article

Phase transitions and structure analysis in wild-type, A30P, E46K, and A53T mutants of α-synuclein.

European biophysics journal : EBJ - 1 May 2016

Healey Mark A, Woodside Michael T, Tuszynski Jack A

Abstract excerpt

α-Synuclein has been implicated in the development of neural plaques in Parkinson's Disease and Lewy-Body Dementia. This paper reports on the structural phase change behavior exhibited over a relevant range of temperatures in canonical protein Monte Carlo simulations for wild-type α-synuclein and three of its familial variants. We performed and analyzed these simulations to determine residue occupancy variations...

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PMID: 26695014
DOI: 10.1007/s00249-015-1103-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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