Article
Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency.
American journal of respiratory and critical care medicine - 15 May 2016
Sorio Claudio, Montresor Alessio, Bolomini-Vittori Matteo, Caldrer Sara, Rossi Barbara, Dusi Silvia, Angiari Stefano, Johansson Jan E, Vezzalini Marzia, Leal Teresinha, Calcaterra Elisa, Assael Baroukh M, Melotti Paola, Laudanna Carlo
Abstract excerpt
RATIONALE: Cystic fibrosis (CF) is a common genetic disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Persistent lung inflammation, characterized by increasing polymorphonuclear leukocyte recruitment, is a major cause of the decline in respiratory function in patients with CF and is a leading cause of morbidity and mortality. CFTR is expressed in various cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.