Article
Exome-based case-control association study using extreme phenotype design reveals novel candidates with protective effect in diabetic retinopathy.
Human genetics - 1 Feb 2016
Shtir Corina, Aldahmesh Mohammed A, Al-Dahmash Saad, Abboud Emad, Alkuraya Hisham, Abouammoh Marwan A, Nowailaty Sawsan R, Al-Thubaiti Ghazai, Naim E A, ALYounes B, Binhumaid F S, ALOtaibi A B, Altamimi A S, Alamer F H, Hashem Mais, Abouelhoda Mohamed, Monies Dorota, Alkuraya Fowzan S
Abstract excerpt
UNLABELLED: Diabetic retinopathy (DR) is a common clinical expression of diabetes mellitus-induced vasculopathy and is a major cause of vision loss. Significant gaps remain in our understanding of the molecular pathoetiology of DR, and it is hoped that human genetic approaches can reveal novel targets especially since DR is a heritable trait. Previous studies have focused on genetic risk factors of DR but their...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.