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Article

Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy.

Clinical epigenetics - 31 Oct 2022

Yang Shaopeng, Guo Xiao, Cheng Weijing, Seth Ishith, Bulloch Gabriella, Chen Yifan, Shang Xianwen, Zhu Zhuoting, Huang Wenyong, Wang Wei

Abstract excerpt

BACKGROUND: Aberrant epigenetic modifications such as DNA methylation may contribute to the pathogenesis of DR. We aimed at elucidating the role of novel DNA methylation modifications in diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) using an extreme phenotypic design. METHODS/RESULTS: Two consecutive studies were conducted. A cross-sectional study using an extreme phenotypic design...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36316758
DOI: 10.1186/s13148-022-01354-z
PMCID: PMC9623976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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