Article
Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins.
PloS one - 1 Jan 2015
de Sousa Graziele Fonseca, Lima Maira de Assis, Custodio Débora Fernandes, Freitas Vanessa Morais, Monteiro Gisele
Abstract excerpt
The use of carboplatin in cancer chemotherapy is limited by the emergence of drug resistance. To understand the molecular basis for this resistance, a chemogenomic screen was performed in 53 yeast mutants that had previously presented strong sensitivity to this widely used anticancer agent. Thirty-four mutants were responsive to carboplatin, and from these, 21 genes were selected for further studies because they...
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