Article
Expression, Epigenetic and Genetic Changes of HNF1B in Endometrial Lesions.
Pathology oncology research : POR - 1 Jul 2016
Němejcová Kristýna, Tichá Ivana, Kleiblová Petra, Bártů Michaela, Cibula David, Jirsová Kateřina, Dundr Pavel
Abstract excerpt
Hepatocyte nuclear factor 1-beta (HNF-1-beta) is a transcription factor involved in cancerogenesis of various tumors, including endometrioid carcinoma. We performed comprehensive analysis of HNF-1-beta in lesions of the endometrium, including protein expression and genetic and epigenetic changes. Expression of HNF-1-beta was analyzed immunohistochemically in 320 cases including both tumor and non-tumor...
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