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Article

Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer.

Oxidative medicine and cellular longevity - 1 Jan 2016

Yanar K, Çakatay U, Aydın S, Verim A, Atukeren P, Özkan N E, Karatoprak K, Cebe T, Turan S, Ozkök E, Korkmaz G, Cacına C, Küçükhüseyin O, Yaylım İ

Abstract excerpt

Nitric oxide synthase (eNOS/NOS3) is responsible for the endothelial synthesis of nitric oxide (NO(•)). G894T polymorphism leads to the amino acid substitution from Glu298Asp that causes lower NOS3 activity and basal NO(•) production in NOS3 894T (298Asp) allele carriers compared with the GG homozygotes. NO(•) acts as an antioxidant protecting against Fenton's reaction which generates highly reactive hydroxyl...

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Identifiers

PMID: 26682008
DOI: 10.1155/2016/4985063
PMCID: PMC4670686

Genes

NOS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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