Article
Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model.
Cancer science - 1 Dec 2009
Kai Kazuharu, Nagano Osamu, Sugihara Eiji, Arima Yoshimi, Sampetrean Oltea, Ishimoto Takatsugu, Nakanishi Masaya, Ueno Naoto T, Iwase Hirotaka, Saya Hideyuki
Abstract excerpt
The cancer stem cell (CSC) model, in which a small population of cells within a tumor possesses the ability to self-renew and reconstitute the phenotype of primary tumor, has gained wide acceptance based on evidence over the past decade. It has also been reported that cancer cell lines contain a CSC subpopulation. However, phenotypic differences between CSCs and non-CSCs in cancer cell lines are not better...
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