Article
Fetal growth restriction and methylation of growth-related genes in the placenta.
Epigenomics - 1 Jan 2016
Xiao Xirong, Zhao Yan, Jin Rong, Chen Jiao, Wang Xiu, Baccarelli Andrea, Zhang Yunhui
Abstract excerpt
AIM: To examine the associations between fetal growth restriction (FGR) and DNA methylation of six growth-related genes in human placenta. MATERIALS & METHODS: A total of 181 mother-newborn pairs (80 FGR cases and 101 controls) were enrolled in this case-control study. Placental DNA methylation was measured by bisulfite pyrosequencing. RESULTS: DNA methylation levels of IGF2 and AHRR were positively associated...
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