Article
IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis.
Dermatology (Basel, Switzerland) - 1 Jan 2016
Galluzzo Marco, Boca Andreea Nicoleta, Botti Elisabetta, Potenza Concetta, Malara Giovanna, Malagoli Piergiorgio, Vesa Stefan, Chimenti Sergio, Buzoianu Anca Dana, Talamonti Marina, Costanzo Antonio
Abstract excerpt
BACKGROUND: Psoriasis is characterized by multiple genetic variations. Some of these variations, such as the presence of HLA-Cw6 or TNFAIP3 single-nucleotide polymorphisms (SNPs), have been correlated to the response to biologic treatments. OBJECTIVE: The aim of our study was to evaluate the effects of IL12B and IL6 SNPs on the response to ustekinumab. METHODS: We retrospectively analyzed the genotypes of 64...
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