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A Catalytic DNA Activated by a Specific Strain of Bacterial Pathogen

16 Dec 2015

Abstract excerpt

Pathogenic strains of bacteria are known to cause various infectious diseases and there is a growing demand for molecular probes that can selectively recognize them. Here we report a special DNAzyme (catalytic DNA), RFD-CD1, that shows exquisite specificity for a pathogenic strain of Clostridium difficile (C. difficile). RFD-CD1 was derived by an in vitro selection approach where a random-sequence DNA library was...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 26676768
DOI: 10.1002/anie.201510125

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