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In Vitro Selection of Circular DNA Aptamers for Biosensing Applications

25 Apr 2019

Abstract excerpt

We report on the first effort to select DNA aptamers from a circular DNA library, which resulted in the discovery of two high-affinity circular DNA aptamers that recognize the glutamate dehydrogenase (GDH) from Clostridium difficile, an established antigen for diagnosing Clostridium difficile infection (CDI). One aptamer binds effectively in both the circular and linear forms, the other is functional only in the...

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PMID: 31020784
DOI: 10.1002/anie.201901192

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