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A Highly Specific DNA Aptamer for RNase H2 from Clostridium difficile

7 Jan 2021

Abstract excerpt

Molecular recognition elements with high specificity are of great importance for the study of molecular interactions, accurate diagnostics, drug design, and personalized medicine. Herein, a highly specific DNA aptamer for RNase H2 from Clostridium difficile ( C. difficile ) was generated by SELEX and minimized to 40 nucleotides. The aptamer exhibits a dissociation constant ( K d ) of 1.8 ± 0.5 nM and an...

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PMID: 33410654
DOI: 10.1021/acsami.0c20277

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