Article
Superantigen influence in conjunction with cytokine polymorphism potentiates autoimmunity in systemic lupus erythematosus patients.
Immunologic research - 1 Aug 2016
Dar Sajad Ahmad, Janahi Essam Mohammed Ahmed, Haque Shafiul, Akhter Naseem, Jawed Arshad, Wahid Mohd, Ramachandran Vishnampettai Ganapathysubramanian, Bhattacharya Sambit Nath, Banerjee Basu Dev, Das Shukla
Abstract excerpt
Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated that they profoundly affect the magnitude of polyclonal T cell response, particularly CD4(+) T cells...
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