Enhanced Susceptibility to Superantigen‐Associated Streptococcal Sepsis in Human Leukocyte Antigen–DQ Transgenic Mice

Abstract excerpt

Bacterial superantigens are believed to cause septic shock, although, because of the lack of superantigen-sensitive infection models, proof that superantigenicity underlies shock pathogenesis is lacking. This work demonstrates a clear superantigen effect in septic shock resulting from bacterial infection. Transgenic expression of human leukocyte antigen (HLA)-DQ, but not HLA-DR, specifically augments lymphocyte...

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