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Article

COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain.

Journal of dental research - 1 Sept 2015

Slade G D, Sanders A E, Ohrbach R, Bair E, Maixner W, Greenspan J D, Fillingim R B, Smith S, Diatchenko L

Abstract excerpt

When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal escalation in stress exacerbates risk for TMD, and the effect is amplified by allelic variants in a...

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Source

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Identifiers

PMID: 26198390
DOI: 10.1177/0022034515595043
PMCID: PMC4547321

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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