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Article

Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?

Journal of the neurological sciences - 15 Dec 2015

Jørgensen Carina, Yasmeen Saiqa, Iversen Helle K, Kruuse Christina

Abstract excerpt

Mutations in the gene encoding phosphodiesterase 4D (PDE4D) enzyme are associated with ischemic stroke; however the functional implications of such mutations are not well understood. PDE4D is part of a complex protein family modulating intracellular signalling by cyclic nucleotides. The PDE4 family includes subtypes A-D, all of which show unique intracellular, cellular and tissue distribution. PDE4D is the major...

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Identifiers

PMID: 26671126
DOI: 10.1016/j.jns.2015.11.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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