Article
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.
Nature genetics - 1 Oct 2003
Gretarsdottir Solveig, Thorleifsson Gudmar, Reynisdottir Sigridur Th, Manolescu Andrei, Jonsdottir Sif, Jonsdottir Thorbjörg, Gudmundsdottir Thorunn, Bjarnadottir Sigrun M, Einarsson Olafur B, Gudjonsdottir Herdis M, Hawkins Malcolm, Gudmundsson Gudmundur, Gudmundsdottir Hrefna, Andrason Hjalti, Gudmundsdottir Asta S, Sigurdardottir Matthildur, Chou Thomas T, Nahmias Joseph, Goss Shyamali, Sveinbjörnsdottir Sigurlaug, Valdimarsson Einar M, Jakobsson Finnbogi, Agnarsson Uggi, Gudnason Vilmundur, Thorgeirsson Gudmundur, Fingerle Jurgen, Gurney Mark, Gudbjartsson Daniel, Frigge Michael L, Kong Augustine, Stefansson Kari, Gulcher Jeffrey R
Abstract excerpt
We previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped this locus and tested it for association with stroke. We found the strongest association in the gene encoding phosphodiesterase 4D (PDE4D), especially for carotid and cardiogenic stroke, the forms of stroke re...
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