Article
Spatio-temporal genetic heterogeneity of CTNNB1 mutations in sporadic desmoid type fibromatosis lesions.
Virchows Archiv : an international journal of pathology - 1 Mar 2016
Doyen Jérôme, Duranton-Tanneur Valérie, Hostein Isabelle, Karanian-Philippe Marie, Chevreau Christine, Breibach Florence, Coutts Michael, Dadone Bérengère, Saint-Paul Marie-Christine, Gugenheim Jean, Duffaud Florence, Pedeutour Florence
Abstract excerpt
Desmoid type fibromatosis (DT) is a rare lesion of unclear pathogenesis that most often presents a mutation of the (β-catenin) gene. The natural history and clinical evolution are highly variable between patients and to date there is no consensus on optimal therapy. We report two cases of a patient with multiple DT lesions. Molecular investigations performed in both patients on multiple tumors at different...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.