Article
Multifocal occurrence of extra-abdominal desmoid type fibromatosis - A rare manifestation. A clinicopathological study of 6 sporadic cases and 1 hereditary case.
Annals of diagnostic pathology - 1 Aug 2018
Bekers Elise M, van Broekhoven Danique L M, van Dalen Thijs, Bonenkamp Johan J, van der Geest Ingrid C M, de Rooy Jacky W J, van Gorp Joost M, Creytens David H, de Leng Wendy W J, Scheijen Blanca, Eijkelenboom Astrid, Flucke Uta
Abstract excerpt
Desmoid-type fibromatosis, also called desmoid tumor, is a locally aggressive myofibroblastic neoplasm that usually arises in deep soft tissue with significant potential for local recurrence. It displays an unpredictable clinical course. β-Catenin, the genetic key player of desmoid tumors shows nuclear accumulation due to mutations that prevent its degradation leading to activation of Wnt signaling and...
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