Article
Quantitative proteomics signature profiling based on network contextualization.
Biology direct - 15 Dec 2015
Bin Goh Wilson Wen, Guo Tiannan, Aebersold Ruedi, Wong Limsoon
Abstract excerpt
BACKGROUND: We present a network-based method, namely quantitative proteomic signature profiling (qPSP) that improves the biological content of proteomic data by converting protein expressions into hit-rates in protein complexes. RESULTS: We demonstrate, using two clinical proteomics datasets, that qPSP produces robust discrimination between phenotype classes (e.g. normal vs. disease) and uncovers...
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