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Article

The use of proteases complementary to trypsin to probe isoforms and modifications.

Proteomics - 1 Mar 2016

Trevisiol Stéphane, Ayoub Daniel, Lesur Antoine, Ancheva Lina, Gallien Sébastien, Domon Bruno

Abstract excerpt

The wide diversity of proteins expressed in a cell or a tissue as a result of gene variants, RNA editing or PTMs results in several hundred thousand distinct functional proteins called proteoforms. The large-scale analysis of proteomes has been driven by bottom-up MS approaches. This allowed to identify and quantify large numbers of gene products and perform PTM profiling which yielded a significant number of...

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PMID: 26663565
DOI: 10.1002/pmic.201500379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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