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Article

Mutation screening of germline TP53 mutations in high-risk Chinese breast cancer patients.

BMC cancer - 2 Nov 2020

Kwong Ava, Shin Vivian Yvonne, Ho Cecilia Y S, Au Chun Hang, Slavin Thomas P, Weitzel Jeffrey N, Chan Tsun-Leung, Ma Edmond S K

Abstract excerpt

BACKGROUND: Germline TP53 mutations are associated with Li-Fraumeni syndrome, a severe and rare hereditary cancer syndrome. Despite the rarity of germline TP53 mutations, the clinical implication for mutation carriers and their families is significant. The risk management of TP53 germline mutation carriers is more stringent than BRCA carriers, and radiotherapy should be avoided when possible. METHODS: TP53 gene...

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Identifiers

PMID: 33138793
DOI: 10.1186/s12885-020-07476-y
PMCID: PMC7607817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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