Clonal architecture of CXCR4 WHIM-like mutations in Waldenström Macroglobulinaemia.

doi:10.1111/bjh.13897

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Article

Clonal architecture of CXCR4 WHIM-like mutations in Waldenström Macroglobulinaemia.

British journal of haematology - 1 Mar 2016

Xu Lian, Hunter Zachary R, Tsakmaklis Nicholas, Cao Yang, Yang Guang, Chen Jie, Liu Xia, Kanan Sandra, Castillo Jorge J, Tai Yu-Tzu, Zehnder James L, Brown Jennifer R, Carrasco Ruben D, Advani Ranjana, Sabile Jean M, Argyropoulos Kimon, Lia Palomba M, Morra Enrica, Trojani Alessandra, Greco Antonino, Tedeschi Alessandra, Varettoni Marzia, Arcaini Luca, Munshi Nikhil M, Anderson Kenneth C, Treon Steven P

Abstract excerpt

CXCR4(WHIM) somatic mutations are distinctive to Waldenström Macroglobulinaemia (WM), and impact disease presentation and treatment outcome. The clonal architecture of CXCR4(WHIM) mutations remains to be delineated. We developed highly sensitive allele-specific polymerase chain reaction (AS-PCR) assays for detecting the most common CXCR4(WHIM) mutations (CXCR4(S338X C>A and C>G) ) in WM. The AS-PCR assays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26659815
DOI: 10.1111/bjh.13897
PMCID: PMC5409813

Genes

CXCR4
MYD88

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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