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Article

Bone marrow involvement and subclonal diversity impairs detection of mutated CXCR4 by diagnostic next-generation sequencing in Waldenström macroglobulinaemia.

British journal of haematology - 1 Aug 2021

Gustine Joshua N, Xu Lian, Yang Guang, Liu Xia, Kofides Amanda, Tsakmaklis Nicholas, Munshi Manit, Demos Maria, Guerrera Maria L, Meid Kirsten, Patterson Christopher J, Sarosiek Shayna, Branagan Andrew R, Hunter Zachary R, Castillo Jorge J, Treon Steven P

Abstract excerpt

CXCR4 mutations impact disease presentation and treatment outcomes in Waldenström macroglobulinaemia (WM). Non-uniform testing for CXCR4 mutations may account for discordant findings in WM clinical trials. We compared two approaches used in these trials for detection of the most common CXCR4 (S338X) variant: targeted next-generation sequencing (NGS) using unselected bone marrow (BM) samples, and combined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33713429
DOI: 10.1111/bjh.17385
PMCID: PMC9113056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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