Article
Dengue Virus Directly Stimulates Polyclonal B Cell Activation.
PloS one - 1 Jan 2015
Correa Arturo Ramon Vargas, Berbel Ana Carolina Egypto Rosa, Papa Michelle Premazzi, Morais Ana Theresa Silveira de, Peçanha Ligia Maria Torres, Arruda Luciana Barros de
Abstract excerpt
Dengue infection is associated to vigorous inflammatory response, to a high frequency of activated B cells, and to increased levels of circulating cross-reactive antibodies. We investigated whether direct infection of B cells would promote activation by culturing primary human B lymphocytes from healthy donors with DENV in vitro. B cells were susceptible, but poorly permissive to infection. Even though, primary B...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.