Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SRT1720 Induces Lysosomal-Dependent Cell Death of Breast Cancer Cells

20 Nov 2014

Abstract excerpt

SRT1720 is an activator of SIRT1, a NAD(+)-dependent protein and histone deacetylase that plays an important role in numerous biologic processes. Several studies have illustrated that SRT1720 treatment could improve metabolic conditions in mouse models and in a study in cancer SRT1720 caused increased apoptosis of myeloma cells. However, the effect of SRT1720 on cancer may be complex, as some recent studies have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Calcium signaling and nucleotide metabolism
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25411356
DOI: 10.1158/1535-7163.mct-14-0584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

SRT1720 Induces Lysosomal-Dependent Cell Death of Breast Cancer CellsPMID 25411356Read ↗

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent PathwaySemantic proximity Read ↗

Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancerSemantic proximity Read ↗

Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell linesSemantic proximity Read ↗

Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.Semantic proximity Read ↗

Targeting SIRT1-regulated autophagic cell death as a novel therapeutic avenue for cancer preventionSemantic proximity Read ↗

Dual Role of Lysosome in Cancer Development and ProgressionSemantic proximity Read ↗

Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer StrategySemantic proximity Read ↗

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.