Article
Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo.
Oncotarget - 5 Jan 2016
Verone-Boyle Alissa R, Shoemaker Suzanne, Attwood Kristopher, Morrison Carl D, Makowski Andrew J, Battaglia Sebastiano, Hershberger Pamela A
Abstract excerpt
Epidemiologic studies implicate vitamin D status as a factor that influences growth of EGFR mutant lung cancers. However, laboratory based evidence of the biological effect of vitamin D in this disease is lacking. To fill this knowledge gap, we determined vitamin D receptor (VDR) expression in human lung tumors using a tissue microarray constructed of lung cancer cases from never-smokers (where EGFR gene...
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