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Article

Differential response to 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in non-small cell lung cancer cells with distinct oncogene mutations.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2013

Zhang Qiuhong, Kanterewicz Beatriz, Shoemaker Suzanne, Hu Qiang, Liu Song, Atwood Kristopher, Hershberger Pamela

Abstract excerpt

We previously demonstrated that non-small cell lung cancer (NSCLC) cells and primary human lung tumors aberrantly express the vitamin D3-catabolizing enzyme, CYP24, and that CYP24 restricts transcriptional regulation and growth control by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in NSCLC cells. To ascertain the basis for CYP24 dysregulation, we assembled a panel of cell lines that represent distinct molecular...

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Identifiers

PMID: 23026510
DOI: 10.1016/j.jsbmb.2012.09.022
PMCID: PMC3674199

Genes

EGFR
VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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