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Article

Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation.

The American journal of psychiatry - 1 May 2016

Ross Randal G, Hunter Sharon K, Hoffman M Camille, McCarthy Lizbeth, Chambers Betsey M, Law Amanda J, Leonard Sherry, Zerbe Gary O, Freedman Robert

Abstract excerpt

OBJECTIVE: α7-Nicotinic receptors are involved in the final maturation of GABA inhibitory synapses before birth. Choline at levels found in the amniotic fluid is an agonist at α7-nicotinic receptors. The authors conducted a double-blind placebo-controlled trial to assess whether high-dose oral phosphatidylcholine supplementation during pregnancy to increase maternal amniotic fluid choline levels would enhance...

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Source

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Identifiers

PMID: 26651393
DOI: 10.1176/appi.ajp.2015.15091188
PMCID: PMC5892450

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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