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Article

Absence of germline CDKN2A mutation in Sicilian patients with familial malignant melanoma: Could it be a population-specific genetic signature?

Cancer biology & therapy - 1 Jan 2016

Di Lorenzo Sara, Fanale Daniele, Corradino Bartolo, Caló Valentina, Rinaldi Gaetana, Bazan Viviana, Giordano Antonio, Cordova Adriana, Russo Antonio

Abstract excerpt

Germline CDKN2A mutations have been described in 25% to 40% of melanoma families from several countries. Sicilian population is genetically different from the people of Europe and Northern Italy because of its historical background, therefore familial melanoma could be due to genes different from high-penetrance CDKN2A gene. Four hundred patients with cutaneous melanoma were observed in a 6-years period at the...

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Share to Cyclin-Dependent Kinase Inhibitor p16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26650572
DOI: 10.1080/15384047.2015.1108494
PMCID: PMC4847825

Genes

CDK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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