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Characterization of ligurian melanoma families and risk of occurrence of other neoplasia

12 Nov 1999

Abstract excerpt

Germline mutations impairing the p16(INK4)-function have previously been demonstrated to be responsible for genetic predisposition in at least one half of melanoma-prone kindreds of North European origin. Familial melanoma kindreds have also been found to present an increased risk of pancreatic cancer and other cancers, but results relative to more common neoplasias incidence, in particular, are heterogeneous. We...

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PMID: 10508477
DOI: 10.1002/(sici)1097-0215(19991112)83:4<441::aid-ijc2>3.0.co;2-r

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